Despite previous attempts, systematic approaches to include the unknown fraction into analytical workflows are still lacking. Genes of unknown function are among the biggest challenges in molecular biology, especially in microbial systems, where 40–60% of the predicted genes are unknown. Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Denmark.Computing Center, Helmholtz Center for Polar and Marine Research, Germany.University of Bremen and Life Sciences and Chemistry, Germany.Institute of Molecular Biology and Genetics, Seoul National University, Republic of Korea.School of Biological Sciences, Seoul National University, Republic of Korea.Section for Evolutionary Genomics, The GLOBE Institute, University of Copenhagen, Denmark.European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, United Kingdom.Josephine Bay Paul Center, Marine Biological Laboratory, United States.Red Sea Research Centre and Computational Bioscience Research Center, King Abdullah University of Science and Technology, Saudi Arabia.Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, France.Center for Advanced Studies of Blanes CEAB-CSIC, Spanish Council for Research, Spain.Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Alfred Wegener Institute, Germany.Department of Environmental Science, University of Arizona, United States.Department of Marine Biology and Oceanography, Institut de Ciències del Mar (CSIC), Spain.Department of Medicine, University of Chicago, United States.Microbial Genomics and Bioinformatics Research G, Max Planck Institute for Marine Microbiology, Germany.
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